2013 ATS Foundation/Alpha-1 Foundation Research Grant Application Instructions
Timeline for the 2013
ATS Foundation/Alpha-1 Foundation Research Grant
(Funding to begin January 15, 2014)
All deadlines are at 11:59 PM EASTERN
|October 15, 2013||Deadline for submission of letters of intent (LOI)|
|October 16 – October 31, 2013||Review of the LOI’s|
|October 31, 2013||Applicants will receive official notification on their LOI’s|
|December 9, 2013||Submission deadline for full grant applications|
|Late December||Review of grant applications|
|End of December/Early January||Award notifications sent to applicants and institutions|
The grant is explained below, along with the application process, eligibility requirements, instructions, and timeline for the review process.
Please review all eligibility requirements before submitting a full application.
The target audience for this research grant will be investigators interested in research that is relevant to alpha-1 antitrypsin deficiency (Alpha-1). The focus of the research grant will be programs that have a high likelihood to advance the understanding of Alpha-1. Applications are encouraged from international and domestic applicants at any stage of their research careers. Applicants may request up to $40,000/year for 2 years for salaries, supplies or a combination of these two.
The deadline to submit a full application is December 9th.
ELIGIBILITY AND GUIDELINES
Both international and domestic applicants are welcome to apply.
Applicants may apply at any stage of their academic careers.
At least one of the key personnel must be an ATS member at the time of application, and the principal investigator must be an ATS member at the time that the grant is awarded.
Applicants must have completed their primary research training (PhD or sub-specialty fellowship training) by October 1, 2013. They must also have a firm commitment from their home institution for a faculty position by the time the award is disbursed (January 15, 2014).
At the present time, investigators in the following categories are not eligible to apply for ATS Foundation grants:
- US-based trainees who do not hold a Visa that spans the project period of the grant
- Current awardees of the ATS Foundation Research Program
- Individuals who have received 2 ATS Foundation grants
REVIEW PROCESS AND TIMELINE
The ATS Scientific Advisory Committee (SAC) will review the applications. The membership of the SAC is listed on the ATS Website. Additional ad hoc reviewers, especially those with an expertise in Alpha-1, will be invited to participate as needed. Funding decisions will be made on the basis of scientific merit, novelty, and responsiveness to the purpose of the specific grant program.
Click here for the applications.
You must use the same login credentials that you used to submit the letter of intent.
Please a) list the key personnel on your project b) list each of their roles on the project (mentor, consultant, research technician, etc.) c) approximate the total percentage of total effort that the person will contribute to the project.
USING TERMS THAT CAN BE UNDERSTOOD BY A NON-SCIENTIFIC AUDIENCE, please briefly describe what you are investigating, the techniques you will use to support your hypothesis, and how your project will contribute to scientific understanding of your disease of interest.
Note that this General Audience Summary will become public information; therefore, do not include proprietary/confidential information.
Please explain how your research may lead to improved patient outcomes. A patient advocate may help review and vote on your application.
SAC REVIEWERS SUMMARY
Please provide a technical abstract of your proposal, keeping your response to 5000 characters or less.
Where would you take this research after funding ends, and how will this support contribute to your research career development?
LAB RESOURCES AND EQUIPMENT
List the resources that you have available to you that will be needed to complete your project. Describe these resources, and explain how each will contribute to the successful completion of your project. Please note that the limit for this section is two pages.
This document should be divided into six sections:
- Major Equipment
- No page limit
- List citations by number in the order in which they appear in the text.
- Use the following format shown below (“New England Journal of Medicine” style in EndNote and “Annals of Internal Medicine” in Reference Manager).
Kajikawa O, Frevert CW, Lin SM, Goodman RB, Mongovin SM, Wong V, Ballman K, Daubeuf B, Elson G, Martin TR. Gene expression of toll-like receptor-2, toll-like receptor-4 and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia. Gene 2005;3:193-202.
Altemeier WA, Matute-Bello G, Frevert CW, Kawata Y, Kajikawa O, Martin TR, Glenny RW. Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin. Am J Physiol Lung Cell Mol Physiol 2004;164:1949-1958.
RESEARCH PLANS (10 page limit)
PLEASE CHECK: The Research Plan (Sections A-D) must be no longer than 10 pages including pictures with margins at .75 (right and left), .50 (top and bottom), using Arial size 11 font with no less than single-line spacing.
The Research Plan should include sufficient information needed for evaluation of the project. The format for preparing this section is provided below. Be specific and informative, and avoid redundancies.
A. STATEMENT OF PROBLEM AND SPECIFIC AIMS
What do you intend to do?
State the problem concisely and describe the specific aims of the research proposal. What is the hypothesis you will test? What is the experimental paradigm?
B. BACKGROUND AND SIGNIFICANCE
Why is the work important?
Briefly provide the scientific background leading to the present application. Critically evaluate existing knowledge and identify the scientific gaps that the project is intended to fill. If the aims of the proposal are accomplished, how will this affect the scientific field? Where will these studies lead in developing a larger research program?
C. WORK ACCOMPLISHED AND PRELIMINARY STUDIES
What has already been done?
Provide an account of the principal investigator’s preliminary studies pertinent to this application. Preliminary data often aid the reviewers in assessing the likelihood of the success of the proposed project. List any publications, manuscripts accepted for publication, patents, or other printed materials that have resulted from preliminary studies.
D. RESEARCH DESIGN AND METHODS
How are you going to do the work?
Describe the research design and methods that you will use in the proposed studies. Organize this section by the specific aims of the research proposal. Include how the data will be collected, and analyzed, and describe potential problems or limitations. Published or commonly used methods do not need to be described in detail. This section must be written so that reviewers can evaluate the scientific questions, the experimental design, and the likelihood that the experiments will produce interpretable results. Include a tentative timetable showing how you will prioritize the work. Clearly identify collaborations with other investigators at the same or other institutions.
LETTERS OF RECOMMENDATIONS
You are responsible for providing and uploading two (2) reference letters (letters of support). These must be uploaded before you can submit your application. Letters sent directly to the ATS office will NOT be accepted. Letters of support are usually just that - letters from someone not involved in the project but who can emphasize its importance. Similarly, institutional leaders (e.g., division director, chair, dean) can write letters to highlight their commitment for the candidate. A mentor could also be included here. You need to determine the best people to write these letters of support considering that they are included to enhance your application.
Please place all letters of support into a SINGLE ZIP file and upload this file to your application.
LETTER FROM COLLABORATOR
You may also submit letter(s) from collaborator(s) or donor(s) who are providing expertise or reagents needed to accomplish the work. You may submit as many of these letters as you feel are necessary. Please place all letters from collaborators into a SINGLE ZIP filed and upload this file to your application.
Please note that you MUST observe the limits indicated in the biosketch template (For example, publications must end on page 2). Applications with biosketches that do not meet the requirements will be un-submitted. Biosketch templates should be downloaded from here.
RESUBMISSION STATEMENT (2 page limit)
A resubmission is an application that was reviewed in a previous cycle, but was not funded. Please note that an application is not considered a resubmission if it has major changes. Only fill out and upload this form if your application is a resubmission.
In the Resubmission Statement you must:
- Explain how you addressed the scientific critiques of the original application
- Explain how the application has been strengthened and modified since the original submission.
DISCLOSURE OF CONFLICT OF INTERESTS
Many individuals have competing interests that may cause conflicts of interest. Disclosure and review of a potential "conflict of interest" (COI) that might affect an ATS research award doesn't imply that an "outside interest", or a person with such a relationship or interest, is wrong or inappropriate. Nor does it imply criticism of the character or actions of the individual, or of any commercial or non-commercial entities with which an individual may be involved. Rather, ATS COI policies and procedures exist to assure the public of appropriate levels of transparency of the outside interests of participants in official ATS activities, and that official ATS activities are managed in a manner that maintains scientific rigor and independence.
- Disclosure of a real or potential COI will not automatically invalidate an application.
All personal financial relationships with commercial entities (such as pharmaceutical companies and medical device manufacturers), and/or with non-commercial, non-governmental funders (such as private foundations), that are relevant to the application’s subject matter must be disclosed. Such involvement with relevant commercial entities (companies) includes employment or ownership; consultancy(ies); Board or advisory committee service; service on speakers' bureaus or other acceptance of lecture fees directly paid by the company; expert testimony on behalf of the company; research grants; patents received or pending; royalties; and stock ownership or options (excluding mutual funds unless a sector fund concentrated in an industry or industries relevant to the activity).
The ATS "Policy on Tobacco Relationships" requires that individuals with a current tobacco industry relationship not hold certain ATS roles, including that of research awardee. (Note: if the relationship is limited to personal holdings of tobacco stocks or options, divestiture of such holdings. See the policy for details.)
PLEASE RESPOND in the corresponding answer spaces on the online application.
COI 1A: Have you within the past 12 months had a financial interest in a commercial entity (i.e., a “commercial interest”) that could be considered broadly relevant to the subject matter of this proposal, or do you expect to have one during the duration of the grant award period?
COI 1B: If yes, please provide the company name(s) and the type of relationship:
COI 2A: Have you within the past 12 months received financial support from a non-commercial, non-governmental source (such as a private foundation or other non-profit source) that could be perceived as a real or potential conflict of interest relevant to the subject matter of this proposal, and/or do you expect to receive such before the end of the grant award period?
COI 2B: If yes, please provide the organization name(s) and the type of relationship:
COI 3A: Have you within the past 12 months had any non-financial affiliation or interest (i.e., a personal, professional or other affiliation or interest) that might be perceived to be a real or potential conflict of interest relevant to the subject matter of this proposal, and/or do you expect to receive such before the end of the grant award period?
COI 3B: If yes, please provide the company or organization name(s) and the type of relationship:
COI 4A: Have you within the past 12 months had a professional relationship with a tobacco entity or expect to have one before the end of the grant award period?
COI 4B: If yes, please provide the company or organization name(s) and the type of relationship:
After you complete all of the proposal sections, you must print the signature page available here, sign it and have your financial administrator sign it. Then, upload the signed page back onto the application as an attachment. Please only upload one signed page. Please do NOT mail the signature page to the ATS office.
Click here to complete the budget form.